Journal of Antimicrobial Chemotherapy

Leading article

Get checked abstract Bénédicte Roquebert and Anne-Geneviève Marcelin

The involvement of HIV-1 RNAse H in resistance to nucleoside analogues
JAC Advance Access published on March 5, 2008
J. Antimicrob. Chemother. 2008 61: 973-975; doi:10.1093/jac/dkn060 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Review

Get checked abstract Dilip Nathwani, Marina Morgan, Robert G. Masterton, Matthew Dryden, Barry D. Cookson, Gary French, and Deirdre Lewis on behalf of the British Society for Antimicrobial Chemotherapy Working Party on Community-onset MRSA Infections

Guidelines for UK practice for the diagnosis and management of methicillin-resistant Staphylococcus aureus (MRSA) infections presenting in the community
JAC Advance Access published on March 13, 2008
J. Antimicrob. Chemother. 2008 61: 976-994; doi:10.1093/jac/dkn096 [Abstract] [FREE Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Original research

Get checked abstract Emiko Rimbara, Norihisa Noguchi, Takashi Kawai, and Masanori Sasatsu

Mutations in penicillin-binding proteins 1, 2 and 3 are responsible for amoxicillin resistance in Helicobacter pylori
JAC Advance Access published on February 14, 2008
J. Antimicrob. Chemother. 2008 61: 995-998; doi:10.1093/jac/dkn051 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Johann D. D. Pitout, Yi Wei, Deirdre L. Church, and Daniel B. Gregson

Surveillance for plasmid-mediated quinolone resistance determinants in Enterobacteriaceae within the Calgary Health Region, Canada: the emergence of aac(6')-Ib-cr
JAC Advance Access published on February 21, 2008
J. Antimicrob. Chemother. 2008 61: 999-1002; doi:10.1093/jac/dkn068 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Yan Jiang, Zhihui Zhou, Ying Qian, Zeqing Wei, Yunsong Yu, Songnian Hu, and Lanjuan Li

Plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in China
JAC Advance Access published on February 25, 2008
J. Antimicrob. Chemother. 2008 61: 1003-1006; doi:10.1093/jac/dkn063 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Annabelle Cesaro, Romain Roth Dit Bettoni, Christine Lascols, Audrey Mérens, Claude James Soussy, and Emmanuelle Cambau

Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes
JAC Advance Access published on March 6, 2008
J. Antimicrob. Chemother. 2008 61: 1007-1015; doi:10.1093/jac/dkn077 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Joaquim Ruiz, Laura Mensa, Maria J. Pons, Jordi Vila, and Joaquim Gascon

Development of Escherichia coli rifaximin-resistant mutants: frequency of selection and stability
JAC Advance Access published on March 5, 2008
J. Antimicrob. Chemother. 2008 61: 1016-1019; doi:10.1093/jac/dkn078 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Yi-Fang Liu, Jing-Jou Yan, Wen-Chien Ko, Shu-Huei Tsai, and Jiunn-Jong Wu

Characterization of carbapenem-non-susceptible Escherichia coli isolates from a university hospital in Taiwan
JAC Advance Access published on February 20, 2008
J. Antimicrob. Chemother. 2008 61: 1020-1023; doi:10.1093/jac/dkn049 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Olivier Clermont, Marie Lavollay, Sophie Vimont, Catherine Deschamps, Christiane Forestier, Catherine Branger, Erick Denamur, and Guillaume Arlet

The CTX-M-15-producing Escherichia coli diffusing clone belongs to a highly virulent B2 phylogenetic subgroup
JAC Advance Access published on March 11, 2008
J. Antimicrob. Chemother. 2008 61: 1024-1028; doi:10.1093/jac/dkn084 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract L. M. Aragón, B. Mirelis, E. Miró, C. Mata, L. Gómez, A. Rivera, P. Coll, and F. Navarro

Increase in β-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type β-lactamases
JAC Advance Access published on February 20, 2008
J. Antimicrob. Chemother. 2008 61: 1029-1032; doi:10.1093/jac/dkn056 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ayla Ergani-Ozcan, Thierry Naas, Betil Ozhak Baysan, Dilara Ogunc, Dilara Inan, Dilek Colak, and Patrice Nordmann

Nosocomial outbreak of vancomycin-resistant Enterococcus faecium in a paediatric unit at a Turkish university hospital
JAC Advance Access published on March 4, 2008
J. Antimicrob. Chemother. 2008 61: 1033-1039; doi:10.1093/jac/dkn066 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract F. McLaws, I. Chopra, and A. J. O'Neill

High prevalence of resistance to fusidic acid in clinical isolates of Staphylococcus epidermidis
JAC Advance Access published on February 25, 2008
J. Antimicrob. Chemother. 2008 61: 1040-1043; doi:10.1093/jac/dkn071 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Subhajit Biswas, Gerald Kleymann, Mihaiela Swift, Laurence S. Tiley, Jonathan Lyall, Jesús Aguirre-Hernández, and Hugh J. Field

A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase–primase inhibitors in their mode of interaction with the antiviral target
JAC Advance Access published on February 25, 2008
J. Antimicrob. Chemother. 2008 61: 1044-1047; doi:10.1093/jac/dkn057 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Eszter Papp, Izabella Gadawski, and Hélène C. F. Côté

Longitudinal effects of thymidine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells
JAC Advance Access published on February 28, 2008
J. Antimicrob. Chemother. 2008 61: 1048-1052; doi:10.1093/jac/dkn067 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract K. Driffield, K. Miller, J. M. Bostock, A. J. O'Neill, and I. Chopra

Increased mutability of Pseudomonas aeruginosa in biofilms
JAC Advance Access published on February 6, 2008
J. Antimicrob. Chemother. 2008 61: 1053-1056; doi:10.1093/jac/dkn044 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract John D. Perry, Larissa Laine, Susan Hughes, Audrey Nicholson, Angela Galloway, and F. Kate Gould

Recovery of antimicrobial-resistant Pseudomonas aeruginosa from sputa of cystic fibrosis patients by culture on selective media
JAC Advance Access published on March 3, 2008
J. Antimicrob. Chemother. 2008 61: 1057-1061; doi:10.1093/jac/dkn081 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Elke Peeters, Hans J. Nelis, and Tom Coenye

Resistance of planktonic and biofilm-grown Burkholderia cepacia complex isolates to the transition metal gallium
JAC Advance Access published on February 26, 2008
J. Antimicrob. Chemother. 2008 61: 1062-1065; doi:10.1093/jac/dkn072 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Gargi Sen, Sibabrata Mukhopadhyay, Manju Ray, and Tuli Biswas

Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity
JAC Advance Access published on February 19, 2008
J. Antimicrob. Chemother. 2008 61: 1066-1075; doi:10.1093/jac/dkn053 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Liliana Rodrigues, Dirk Wagner, Miguel Viveiros, Daniela Sampaio, Isabel Couto, Martina Vavra, Winfried V. Kern, and Leonard Amaral

Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis
JAC Advance Access published on February 29, 2008
J. Antimicrob. Chemother. 2008 61: 1076-1082; doi:10.1093/jac/dkn070 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract C. Martín de la Escalera, A. I. Aller, E. López-Oviedo, A. Romero, A. I. Martos, E. Cantón, J. Pemán, P. García Martos, and E. Martín-Mazuelos

Activity of BAL 4815 against filamentous fungi
JAC Advance Access published on March 7, 2008
J. Antimicrob. Chemother. 2008 61: 1083-1086; doi:10.1093/jac/dkn076 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Eva M. Kulik, Krystyna Lenkeit, Stephan Chenaux, and Jürg Meyer

Antimicrobial susceptibility of periodontopathogenic bacteria
JAC Advance Access published on March 7, 2008
J. Antimicrob. Chemother. 2008 61: 1087-1091; doi:10.1093/jac/dkn079 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Thomas R. Fritsche, Paul R. Rhomberg, Helio S. Sader, and Ronald N. Jones

Antimicrobial activity of omiganan pentahydrochloride tested against contemporary bacterial pathogens commonly responsible for catheter-associated infections
JAC Advance Access published on February 29, 2008
J. Antimicrob. Chemother. 2008 61: 1092-1098; doi:10.1093/jac/dkn074 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Warren E. Rose, Glenn W. Kaatz, George Sakoulas, and Michael J. Rybak

Teicoplanin pharmacodynamics in reference to the accessory gene regulator (agr) in Staphylococcus aureus using an in vitro pharmacodynamic model
JAC Advance Access published on February 8, 2008
J. Antimicrob. Chemother. 2008 61: 1099-1102; doi:10.1093/jac/dkn037 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ana Paula Galvão da Silva, Donovan Unks, Shu-chen Lyu, Jeffrey Ma, Renata Zbozien-Pacamaj, Xi Chen, Alan M. Krensky, and Carol Clayberger

In vitro and in vivo antimicrobial activity of granulysin-derived peptides against Vibrio cholerae
JAC Advance Access published on February 29, 2008
J. Antimicrob. Chemother. 2008 61: 1103-1109; doi:10.1093/jac/dkn058 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Hend M. Shubar, Jan Patino Mayer, Werner Hopfenmüller, and Oliver Liesenfeld

A new combined flow-cytometry-based assay reveals excellent activity against Toxoplasma gondii and low toxicity of new bisphosphonates in vitro and in vivo
JAC Advance Access published on February 19, 2008
J. Antimicrob. Chemother. 2008 61: 1110-1119; doi:10.1093/jac/dkn047 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Partha Palit and Nahid Ali

Oral therapy with sertraline, a selective serotonin reuptake inhibitor, shows activity against Leishmania donovani
JAC Advance Access published on February 13, 2008
J. Antimicrob. Chemother. 2008 61: 1120-1124; doi:10.1093/jac/dkn046 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract R. Espada, S. Valdespina, M. A. Dea, G. Molero, M. P. Ballesteros, F. Bolás, and J. J. Torrado

In vivo distribution and therapeutic efficacy of a novel amphotericin B poly-aggregated formulation
JAC Advance Access published on February 19, 2008
J. Antimicrob. Chemother. 2008 61: 1125-1131; doi:10.1093/jac/dkn048 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Samantha Hodgetts, Lucy Nooney, Raid Al-Akeel, Alan Curry, Sawsan Awad, Ruth Matthews, and James Burnie

Efungumab and caspofungin: pre-clinical data supporting synergy
JAC Advance Access published on February 25, 2008
J. Antimicrob. Chemother. 2008 61: 1132-1139; doi:10.1093/jac/dkn075 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Russell E. Lewis, Nathan D. Albert, and Dimitrios P. Kontoyiannis

Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis
JAC Advance Access published on February 27, 2008
J. Antimicrob. Chemother. 2008 61: 1140-1144; doi:10.1093/jac/dkn069 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jasper van der Lugt, Reshma Saskia Autar, Sasiwimol Ubolyam, Evian Fernandez Garcia, Jongkol Sankote, Anchalee Avihingson, Theshinee Chuenyam, David A. Cooper, Joep Lange, Praphan Phanuphak, Ferdinand Wit, Kiat Ruxrungtham, and David Burger on behalf of the HIV-NAT 019 Study Team

Pharmacokinetics and short-term efficacy of a double-boosted protease inhibitor regimen in treatment-naive HIV-1-infected adults
JAC Advance Access published on February 18, 2008
J. Antimicrob. Chemother. 2008 61: 1145-1153; doi:10.1093/jac/dkn050 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract James C. Hurley

Profound effect of study design factors on ventilator-associated pneumonia incidence of prevention studies: benchmarking the literature experience
JAC Advance Access published on March 8, 2008
J. Antimicrob. Chemother. 2008 61: 1154-1161; doi:10.1093/jac/dkn086 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Carl Asche, Carrie McAdam-Marx, Brian Seal, Benjamin Crookston, and C. Daniel Mullins

Treatment costs associated with community-acquired pneumonia by community level of antimicrobial resistance
JAC Advance Access published on February 29, 2008
J. Antimicrob. Chemother. 2008 61: 1162-1168; doi:10.1093/jac/dkn073 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Oguz Karabay and Salih Hosoglu

Increased antimicrobial consumption following reimbursement reform in Turkey
JAC Advance Access published on February 13, 2008
J. Antimicrob. Chemother. 2008 61: 1169-1171; doi:10.1093/jac/dkn055 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Larissa Grigoryan, Johannes G. M. Burgerhof, John E. Degener, Reginald Deschepper, Cecilia Stålsby Lundborg, Dominique L. Monnet, Elizabeth A. Scicluna, Joan Birkin, and Flora M. Haaijer-Ruskamp on behalf of the Self-Medication with Antibiotics and Resistance (SAR) Consortium

Determinants of self-medication with antibiotics in Europe: the impact of beliefs, country wealth and the healthcare system
JAC Advance Access published on February 22, 2008
J. Antimicrob. Chemother. 2008 61: 1172-1179; doi:10.1093/jac/dkn054 [Abstract] [Full Text] [PDF] [Request Permissions]  

Research letters

M. Gracia, C. Díaz, P. Coronel, M. Gimeno, R. García-Rodas, G. del Prado, L. Huelves, V. Ruiz, P. L. Naves, M. C. Ponte, J. J. Granizo, and F. Soriano

Antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis isolates in eight Central, East and Baltic European countries in 2005–06: results of the Cefditoren Surveillance Study
JAC Advance Access published on March 3, 2008
J. Antimicrob. Chemother. 2008 61: 1180-1181; doi:10.1093/jac/dkn083 [Extract] [Full Text] [PDF] [Request Permissions]  

Guido Werner, Sabine Gfrörer, Carola Fleige, Wolfgang Witte, and Ingo Klare

Tigecycline-resistant Enterococcus faecalis strain isolated from a German intensive care unit patient
JAC Advance Access published on February 18, 2008
J. Antimicrob. Chemother. 2008 61: 1182-1183; doi:10.1093/jac/dkn065 [Extract] [Full Text] [PDF] [Request Permissions]  

Alexandre Prehn Zavascki, Afonso Luís Barth, and Luciano Zubaran Goldani

Nosocomial bloodstream infections due to metallo-β-lactamase-producing Pseudomonas aeruginosa
JAC Advance Access published on March 3, 2008
J. Antimicrob. Chemother. 2008 61: 1183-1185; doi:10.1093/jac/dkn082 [Extract] [Full Text] [PDF] [Request Permissions]  

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